The emergence of mRNA vaccines, propelled by the COVID-19 pandemic, highlights the vast potential of mRNA in addressing unmet therapeutic needs. mRNA technology has achieved notable maturity in infectious disease vaccines and tumor immunotherapy. As a versatile platform, it has also driven significant advancements in in vivo and in vitro gene editing, cell therapy, protein replacement therapy, and regenerative medicine.

XGen's mRNA production platform streamlines the entire workflow, from gene synthesis to in vitro transcription, enabling the efficient production of high-quality, large-scale DNA templates and mRNA reagents. Our solutions are tailored to support mRNA vaccine development and therapeutic research, accelerating your innovation and discovery efforts.

One-Stop Solution for All Your mRNA Needs

XGen’s solution for IVT mRNA manufacturing streamlines your workflow, from gene synthesis to mRNA production. Our IVT mRNAs are optimized using our proprietary production platform, ensuring high quality and expression efficiency.

Quality Control and Specification

FAQs

What is the length limit of XGen's mRNA production capability?

We can make mRNA from 100 n.t. to 20,000 n.t. in length. 

What are the differences between RUO and preclinical grade mRNA?

For RUO grade mRNA, we use LiCl precipition method for purification. It is suitable for in vitro and in vivo proof of concept studies.

For preclinical grade mRNA, we use Oligo dT purification to improve RNA purity.

Can XGen provide GMP-grade mRNA?

Yes

Do you guarantee the yield of the mRNA?

Yes

What concentratio of mRNA can you produce?

We provide mRNA at a concentration of 0.2-2 mg/mL by default. We can adjust the concentration to up to 4mg/mL upon customer's request

What buffer options does XGen offer for mRNA?

1mM sodium citrate (pH 6.5)

TE buffer (pH7)

RNase-Free water.