XGen has launched the INano series lipid nanoparticle transfection reagent kits for efficient RNA delivery at the cellular level. By leveraging lipid hydrophobicity and charge interactions, RNA-LNP encapsulation can be achieved with simple manual mixing. This process is quick and easy, without the need for subsequent ultrafiltration or buffer exchange steps. This streamlined process significantly reduces experiment cycles while enabling efficient, precise, fast, cost-effective, and safe cell-level validation. XGen offers a range of transfection kits tailored for different RNA types, cell types, and RNA mechanisms, making them ideal for mRNA, circRNA, saRNA, and siRNA, and more.

• Ready-to-use: Simply mix the sample and it's ready to go

• Cost-effective: Enables preparation of small sample quantities

• Efficient: Short preparation times, allowing for rapid integration in experiments

• Good reproducibility: Uniform physicochemical properties and high sample encapsulation efficiency

• Good stability: The reagent kit can be stored at room temperature for up to one month

• High transfection efficiency: Achives significantly higher in vitro transfection efficiency compared to the benchmark LNP formulations, with comparable in vivo protein expression

• Scalable: Compatible with XGen's equipment for large-scale production, resulting in smaller particle size and an encapsulation efficiency of up to 90%

XGen has developed a variety of cell transfection reagent kits that achieve exceptional transfection efficiency (>90%) across commonly used tumor cell lines, including B16F10, A549, HEK293T, DC2.4, Jurkat T, and more. Additionally, XGen has developed specialized transfection kits for specific cell types, such as primary T cells and mesenchymal stem cells, delivering transfection efficiencies of over 80%.

Tumor Cell Transfection Kit

T Cell Transfection Kit

Stem Cell Transfection Kit

In recent years, RNA has unlocked numerous new applications in various fields, including infectious disease vaccines, cancer vaccines, gene editing, and protein replacement therapies. To support the research needs of scientists and companies, XGen has developed specialized reagent kits suitable for different applications. These kits deliver excellent performance, often matching or even surpassing the effectiveness of the commercially available SM-102 LNP.

Protein Replacement Kit

The GenNano™-LNP-mRNA Reagent enables efficient target protein expression in mice, significantly outperfoming the publicly available formulation.

Gene Editing Kit

Vaccine Encapsulation Kit

XGen has developed reagent kits for organ specific targeting, allowing for targeted RNA delivery based on customer needs. The liver-targeting delivery reagent kit is currently available, achieving 90% total protein expression in the liver. Additionally, a spleen-targeting reagent kit has been introduced, achieving over 50% total protein expression in the spleen.

Liver-Targeting Kit	Spleen-Targeting Kit

Heart  Liver  Spleen  Lungs  Kidneys	Heart   Liver  Spleen  Lungs  Kidneys

In recent years, with the launch of mRNA vaccines, SM-102 LNP and ALC-0315 LNP have been extensively validated for their effectiveness and safety in preclinical and clinical studies, making them the preferred choice as positive controls for research. Additionally, SM-102 LNP and ALC-0315 LNP can also be used for early pipeline development validation or instrument calibration. In response to these customer needs, XGen has developed corresponding validation kits and looks forward to providing these reagents to customers.