INano™ HT-Smart
End-to-End High-Throughput mRNA/LNP Screening Workstation
INano™ L+
Rapid Nanomedicine Preparation System
INano™ Optimux
Medium-Scale Formulation (Reusable System & GMP Compliant)
INano™ S
Commercial LNP Manufacturing System
Cell Transfection Kit
Application Kit
Organ-specific Targeting Kit
Validation Kit
DNA-LNP Kit
Protein-LNP Kit
The INano™ HT-Smart system enables full-process, high-throughput formulation automation, from automatic lipid mixing to the automated purification of mRNA-LNP final products. It meets the high-throughput in vivo and in vitro screening needs for large-scale cationic lipid screening, lipid formulation optimization, mRNA sequence screening, and LNP preparation process optimization.
Preparation of the 96-lipid mix: < 30 min
Synthesis of 96-LNP formulations: < 3 hours
Single-Formulation Preparation Volume: ≥ 300 uL
Unique and fully automated in-line dialysis process, enabling true end-to-end high-throughput screening
Reusable microfluidic mixer or T-mixer
Seamlessly integrates with subsequent scale-up production platforms
Built-in algorithms with 'one-click' smart operation for ease of use
A “True” High-Throughput LNP/mRNA Screening System
INanoTM HT-Smart seamlessly integrates four core functions: ionizable lipid screening, lipid composition optimization, mRNA sequence screening, and LNP formulation process exploration.
Additionally, It features workflows for automated lipid mix preparation, and downstream buffer exchange, providing researchers with a comprehensive, all-in-one high-throughput screening solution.
Maximize Your Freedom With a Range of Mixing Structures
As a platform device, the INano™ HT-Smart supports various types of mixing structures, including microfluidic mixers, T-mixers, and other customized mixers, maximizing flexibility.
High Batch-to-Batch Reproducibility
INano™ HT-Smart adopts advanced automated microfluidic technology, enabling efficient production of various formulations. Results from empty LNPs show high batch-to-batch reproducibility, with outcomes closely matching those from INano L+ (scale-up).
Efficient and Low-Cost
Compared to traditional microfluidic preparation devices, INano™ HT-Smart offers lower operational costs and reduced time investment, enabling significant savings in R&D expenses.
Fully Automated In-Line Buffer Exchange System
Thanks to the innovative patented design of INano's fully automated buffer exchange system, users can perform in-line buffer exchange on 96 samples, with a process that is fully adjustable to meet their needs.
High Scale-Up Consistency
INano™ HT-Smart supports a minimum single sample preparation volume of 300 μL, significantly reducing material consumption during early formulation exploration stages. The formulations screened can be scaled up with consistent results on both INano™ and XNano™ devices, providing an efficient and cost-effective solution for the R&D process.
360° Comprehensive Protection
The INano™ HT-Smart features an efficient air filtration system, a temperature control module, and a UV sterilization module to effectively mitigate issues such as mRNA degradation, lipid precipitation, and endotoxin contamination. With customizable cleaning processes between sample batches, it ensures reliable and consistent experimental results allowing you to focus entirely on your experimental design.
Error-Proof One-Click Operation
The INanoTM HT-Smart is equipped with validated, industry-recognized formulation algorithms, eliminating the need for complex inputs. Simply enter your desired parameters, and with one click, initiate an efficient experimental process without the risk of human error.
